1899 Hoffenheim vs Lyon prediction, odds and how to watch

Lens came from behind to beat Lyon 2-1 in Ligue 1, with substitute Khalis Merah settling the match in the 85th minute after Matthieu Udol handed the home side a man advantage with a red card a minute earlier.

Lyon dismantled Rennes 4-0 at home in Ligue 1, with Ernest Nuamah scoring twice before half-time and Rennes never once threatening to compete at the required level. This was a statement performance built on basics, not luck.

OFI produced a disciplined, combative performance to beat 1899 Hoffenheim 2-0 in the UEFA Europa League, with Aitor Cantalapiedra and Georgios Kanellopoulos scoring to give the Cretan side a deserved victory. Hoffenheim had the ball but OFI had the desire.

Lyon took all three points in Brussels with a 2-1 victory over Anderlecht in the UEFA Europa League, but Anderlecht's goalkeeper made eight saves and the home side hit the woodwork. Lyon did the basics when it mattered. Anderlecht did not.

Adam Hlozek scored twice to give 1899 Hoffenheim a deserved 2-1 victory over VfB Stuttgart, handing the visitors a third defeat in five Bundesliga matches and raising serious questions about Stuttgart's defensive accountability.

Hoffenheim host Lyon in the UEFA Europa League on Thursday 22 October 2026 with very different opening results behind them. One side needs a response. The other wants to build momentum.

Lyon host Nice in Ligue 1 on Sunday evening knowing three points are there for the taking. Nice have not won a single match in their last ten on the road. That tells you everything.

Crystal Palace travel to Lyon on Thursday evening carrying serious momentum after a dominant 4-0 opening win in Europe. Lyon will be looking to build on their own winning start, but Palace look like a side with something to prove on the continent.